A 34-year-old woman is referred after a colonoscopy that revealed >100 polyps throughout her colon and rectum (Fig. 1). A random selection of 3 polyps is biopsied and reported as adenomas. She is adopted and is unaware of her biological family. She is found to have a deleterious germline variant in APC (c.1967-1974del). She works as a nurse and is married with 4 children (age: 17, 13, 11, and 6 years). She has had no prior abdominal operations.
Department of Colorectal Surgery, Digestive Disease & Surgery Institute, Cleveland Clinic, Cleveland, Ohio
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Funding Support: None reported.
Financial Disclosure: None reported.
Correspondence: Vladimir Bolshinsky, M.B.B.S., Dip.Surg.Anat., F.R.A.C.S., Cleveland Clinic, Colorectal Surgery, 9500 Euclid Ave/A30, Cleveland, OH 44195. E-mail: firstname.lastname@example.org