Correctly predicting the depth of tumor invasion in the colorectal wall is crucial for successful endoscopic resection of superficial colorectal neoplasms.
The aim of this study was to assess the accuracy of magnifying chromoendoscopy in a Western medical center to predict the depth of invasion by the pit pattern classification in patients with colorectal neoplasms with a high risk of submucosal invasion.
This single-center retrospective study, from a prospectively collected database, was conducted between April 2009 and June 2015.
The study was conducted at a single academic center.
Consecutive patients with colorectal neoplasms with high risk of submucosal invasion were included. These tumors were defined by large (≥20 mm) sessile polyps (nonpedunculated), laterally spreading tumors, or depressed lesions of any size.
Patients underwent magnifying chromoendoscopy and were classified according to the Kudo pit pattern. The therapeutic decision, endoscopic or surgery, was defined by the magnification assessment.
Sensitivity, specificity, and positive and negative predictive values of magnifying chromoendoscopy for assessment of these lesions were determined.
A total of 123 lesions were included, with a mean size of 54.0 ± 37.1 mm. Preoperative magnifying chromoendoscopy with pit pattern classification had 73.3% sensitivity, 100% specificity, 100% positive predictive value, 96.4% negative predictive value, and 96.7% accuracy to predict depth of invasion and consequently to guide the appropriate treatment. Thirty-three rectal lesions were also examined by MRI, and 31 were diagnosed as T2 lesions. Twenty two (70.1%) of these lesions were diagnosed as noninvasive by magnifying colonoscopy, were treated by endoscopic resection, and met the curative criteria.
This was a single-center retrospective study with a single expert endoscopist experience.
Magnifying chromoendoscopy is highly accurate for assessing colorectal neoplasms suspicious for submucosal invasion and can help to select the most appropriate treatment. See Video Abstract at http://links.lww.com/DCR/A920.
1 Division of Endoscopy, Cancer Institute of University of São Paulo Medical School, São Paulo, Brazil
2 Division of Pathology, Cancer Institute of University of São Paulo Medical School, São Paulo, Brazil
3 Division of Gastrointestinal Surgery, Cancer Institute of University of São Paulo Medical School, São Paulo, Brazil
Funding/Support: None reported.
Financial Disclosure: None reported.
Presented in part at the meeting of United European Gastroenterology Week 2015, Barcelona, Spain, October 24 to 28, 2015, and the poster was awarded a National Scholar Award–Brazil.
Correspondence: Fabio S. Kawaguti, M.D., Cancer Institute of University of Sao Paulo, Dr Arnaldo Av, 251, 2o Andar, 01246-000 São Paulo, Brazil. E-mail: firstname.lastname@example.org