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Revisional and Reconstructive Surgery for Failing IPAA is Associated with Good Function and Pouch Salvage in Highly Selected Patients

Lightner, Amy L., M.D.1; Shogan, Benjamin D., M.D.2; Mathis, Kellie L., M.D.1; Larson, David W., M.D.1; Duchalais, Emilie, B.A.1; Pemberton, John H., M.D.1; Dozois, Eric J., M.D.1

Diseases of the Colon & Rectum: August 2018 - Volume 61 - Issue 8 - p 920–930
doi: 10.1097/DCR.0000000000001130
Original Contributions: Inflammatory Bowel Disease
Denotes CME
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BACKGROUND: Revisional and reconstructive surgery for IPAA is rare given the high success of pouch surgery for chronic ulcerative colitis. Limited data exist on both surgical and functional outcomes in patients with chronic ulcerative colitis who undergo IPAA revision or reconstruction.

OBJECTIVE: This study aimed to determine the surgical and functional outcome in patients with chronic ulcerative colitis who undergo IPAA revision or reconstruction.

DESIGN: A prospectively collected surgical database was accessed for this study.

SETTING: This study was conducted at an IBD referral center.

PATIENTS: Patients with chronic ulcerative colitis who underwent IPAA revision or reconstruction were selected.

MAIN OUTCOME MEASURES: The primary outcomes measured were 30-day postoperative outcomes and long-term pouch function.

RESULTS: Eighty-one patients were identified. Original IPAA was performed for chronic ulcerative colitis (n = 71; 88%) and indeterminate colitis (n = 11; 12.%), and the most common configuration was a J-pouch (n = 69; 86%) with handsewn anastomosis (n = 41;68%). No independent predictors of 30-day postoperative complications following reconstructive/revisional surgery were identified. Pelvic abscesses and Crohn’s disease of the pouch were independently associated with ultimate pouch excision. Median follow-up following revision/reconstruction was 40 months (range, 1–292 months) during which 15 patients (23%) had pouch failure. The 5- and 10-year pouch survival rates following revision were 85 ± 5% and 65 ± 9% by Kaplan-Meier estimation; age <30 years was significantly associated with pouch survival. Long-term function (n = 30; 35%) compared with a matched control cohort of primary IPAA was characterized by significantly increased daytime bowel incontinence (p = 0.0119), liquid stool (p = 0.0062), and medication to thicken stools (p = 0.0452).

LIMITATIONS: This was a single-center series, and response rate for functional data was 35%.

CONCLUSIONS: In properly selected patients with a failing pouch, originally made for chronic ulcerative colitis or indeterminate colitis, revisional and reconstructive surgery is associated with low complication rates, high pouch salvage, and acceptable long-term pouch function. See Video Abstract at

1 Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, Minnesota

2 Department of Surgery, University of Chicago, Chicago, Illinois

Earn Continuing Medical Education (CME) credit online at

Support/Funding: None reported.

Financial Disclosures: None reported.

Poster presentation at the meeting of The American Society of Colon and Rectal Surgeons, Seattle, WA, June 10 to 14, 2017.

Correspondence: Amy Lightner, M.D., 200 1st St SW, Rochester, MN 55905. E-mail:

© 2018 The American Society of Colon and Rectal Surgeons