This study was undertaken to determine the outcomes of patients whose complex anal fistulas were managed by ligation of the intersphincteric fistula
tract reinforced with a bioprosthetic graft (BioLIFT procedure).
A retrospective analysis was performed of all patients whose anal fistula
was managed by use of the BioLIFT technique between May 2005 and May 2008, who had a minimum of 1 year of follow-up after their last treatment.
The BioLIFT technique using a bioprosthetic graft was used to treat a complex anal fistula
in 31 patients (22 men, 9 women; mean age, 48 y (range, 30–68 y)). Clinical healing of the fistula
, defined as the absence of drainage with no evidence of residual fistula
tract, occurred in 29 (94%) patients. No complications occurred that required intervention.
The BioLIFT procedure is effective for the management of complex fistulas-in-ano. Randomized clinical trials comparing this technique with other sphincter-preserving methods for fistula
management need to be performed to further determine the role of this technique in the management of anal fistulas.