PURPOSE:: PURPOSE::Despite the universal use of bowel preparation before colonoscopy and colorectal surgery, the physiologic effects have not been described in a standardized setting. This study was designed to investigate the physiologic effects of bowel preparation.
METHODS:: METHODS::In a prospective study, 12 healthy volunteers (median age, 63 years) underwent bowel preparation with bisacodyl and sodium phosphate. Fluid and food intake were standardized according to weight, providing adequate calorie and oral fluid intake. Before and after bowel preparation, weight, exercise capacity, orthostatic tolerance, plasma and extracellular volume, balance function, and biochemical parameters were measured.
RESULTS:: RESULTS::Bowel preparation led to a significant decrease in exercise capacity (median, 9 percent) and weight (median, 1.2 kg). Plasma osmolality was significantly increased from 287 to 290 mmol kg−1, as well as increased phosphate and urea concentrations, whereas calcium and potassium concentrations decreased significantly after bowel preparation. No differences in plasma or extracellular volumes were seen. Orthostatic tolerance and balance function did not change after bowel preparation.
CONCLUSIONS:: CONCLUSIONS::Bowel preparation has significant adverse physiologic effects, which may be attributed to dehydration. The majority of these findings is small and may not be of clinical relevance in otherwise healthy patients undergoing bowel preparation and following recommendations for oral fluid intake.
Supported by grants from the University of Copenhagen and the Danish Research Council (no. 22-01-0160).
Presented at the meeting of the American Society of Anesthesiologists, San Francisco, California, October 11 to 15, 2003.
aDepartment of Surgical Gastroenterology, Hvidovre University Hospital, DK-2650 Hvidovre, Denmark, e-mail: firstname.lastname@example.org
© The ASCRS 2004