Conclusions ConclusionsUsing basically the same reagents and methodology, we have tried to duplicate the optimistic results of Gold et al. Of 578 samples submitted, 393 met the criteria for the study; results for these 393 are presented. Our results indicate that CEA can be detected not only in a smaller proportion of gastrointestinal malignancies than that found by Gold and associates, but also in a similar proportion of inflammatory bowel diseases. Furthermore, we found a significant number of positive in nongastrointestinal malignancies, as well as chronic inflammatory diseases and collagenoses. Therefore, we feel that the assay, in its present form, has limited value as a diagnostic tool in the detection of gastrointestinal malignancies. Better purification procedures, less sensitive methods of detection, or an entirely new approach may produce results of more clinical value than those we have obtained.
Symposium presented at the meeting of the American Proctologic Society Las Vegas, Nevada, May 10 to 13, 1971.
Presented in part at The Southern Medical Association Meeting, Dallas, Texas, November 16, 1970.
Supported in part by grants from the American Cancer Society, Ohio Division, The Randall Foundation, and a donation from Mr. F. Ball.
© The ASCRS 1972