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Prevention of Ventilator-Associated Pneumonia Through Aspiration of Subglottic Secretions: A Systematic Review and Meta-Analysis

Leasure, A. Renee PhD, RN, CCRN, CNS; Stirlen, Joan MPH, BSN, RN; Lu, Shu Hua PhD, RN

Dimensions of Critical Care Nursing: March/April 2012 - Volume 31 - Issue 2 - p 102–117
doi: 10.1097/DCC.0b013e3182445ff3

Ventilator-associated pneumonia (VAP) is a subset of hospital-acquired pneumonias and is a serious, sometimes fatal, complication in patients who need mechanical ventilation. In addition, pay-for-performance initiative has placed increased emphasis on preventing nosocomial infections including VAP. Facilities may not be reimbursed for costs associated with prevalence infections. This article presents a review and meta-analysis of the prevention of VAP through the aspiration of subglottic secretion.

A. Renee Leasure, PhD, RN, CCRN, CNS, is an associate professor at the University of Oklahoma Health Sciences Center and research investigator at the Department of Veterans Affair Medical Center, Oklahoma City. Dr Leasure is a reviewer of manuscripts for DCCN.

Joan Stirlen, MPH, BSN, RN, is a performance measures coordinator at the Office of Performance and Quality, Department of Veterans Affairs Medical Center, Oklahoma City.

Shu Hua Lu, PhD, RN, is an assistant professor at School of Nursing, China Medical University, Taichung, Taiwan.

The authors have disclosed that they have no significant relationship with, or financial interest in, any commercial companies pertaining to this article.

Address correspondence and reprint requests to: A. Renee Leasure, PhD, RN, CCRN, CNS, CNB 316, 1100 N Stonewall, Oklahoma City, OK 73117 (

© 2012 Lippincott Williams & Wilkins, Inc.