Clinical DIMENSIONUpdate on the Management of Infection in Patients With Severe SepsisVandijck, Dominique M. PhD, MSc, MA, RN; Blot, Stijn I. PhD, MSc, RN; Decruyenaere, Johan M. MDAuthor Information Dominique M. Vandijck, PhD, MSc, MA, RN, is a researcher in the intensive care department of the Ghent University Hospital and a researcher in the interfaculty center for health economic research of the faculty of medicine and health sciences at Ghent University. Stijn I. Blot, PhD, MNSc, RN, is a professor in the faculty of medicine and health sciences at Ghent University and Ghent University College and a researcher in the infectious diseases department of the Ghent University Hospital. Johan M. Decruyenaere, MD, is director of the intensive care department of the Ghent University Hospital and a professor in the faculty of medicine and health sciences of Ghent University. Address correspondence and reprint requests to: Dominique M. Vandijck, PhD, MSc, MA, RN, Department of Intensive Care Medicine, Faculty of Medicine and Health Sciences, Ghent University-Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium ([email protected]). Dominique M. Vandijck received a doctoral grant from the Scientific Fund of the Ghent University. Dimensions of Critical Care Nursing: November 2008 - Volume 27 - Issue 6 - p 244-248 doi: 10.1097/01.DCC.0000338868.31917.0e Buy Metrics AbstractIn Brief Morbidity and mortality associated with the development of severe sepsis remain unacceptably high. However, with the introduction of a protocol called early goal-directed therapy, significant benefits in terms of patient's outcome have been demonstrated. In an aim to improve outcome and to increase awareness, practical evidence-based guidelines for the management of severe sepsis and septic shock were developed under the auspices of the Sepsis Surviving Campaign, easy to apply by the bedside medical and nursing staff. The treatment of severe sepsis includes 3 main essentials: (1) eradication of the inciting infection using source control measures and empiric antimicrobials, (2) hemodynamic resuscitation of tissue hypoperfusion using fluids and inotropic drugs to prevent life-threatening organ damage, and (3) sustained organ support using mechanical interventions to diminish organ injury. This review article highlights the anti-infective approach of the management of sepsis. Morbidity and mortality associated with severe sepsis remains high. This paper provides practical evidence-based guidelines for the management of severe sepsis and septic shock. © 2008 Lippincott Williams & Wilkins, Inc.