Applied Pathophysiology: PDF OnlyCandida albicans An opportunistic threat to critically ill low birth weight infantsWitek-Janusek, Linda RN, PhD; Cusack, Cynthia RN, MSN; Mathews, Herbert L PhDAuthor Information Linda Witek-Janusek, RN, PhD, is a professor in the department of maternal child health nursing at Loyola University of Chicago. She has conducted research investigating the pathophysiology of neonatal spesis and the effects of stress on the immune system. She is the principal investigator of a National Institute of Nursing Research grant investigating antifungal defense against C. albicans in low birth weight infants. Cusack, RN, MSN, is a doctoral student in nursing at Loyola University of Chicago and a staff nurse in the neonatal intensive care unit at Loyola University Medical Center. She has also worked as a graduate research assistant in the School of Nursing on a project investigating neonatal candidiasis. Herbert L. Mathews, PhD, is a professor in the department of microbiology and immunology at Loyola University of Chicago. Dr. Mathews has conducted research funded by the National Institutes of Health (NIH) investigating the role of the lymphocyte in host defense for more than 10 years. His current NIH-sponsored research focuses on the role of lymphocytes in host defense against C. albicans. Dimensions of Critical Care Nursing: September 1998 - Volume 17 - Issue 5 - p 243-255 Buy Abstract Major advances in the management of critically ill low birth weight (LBW) infants have increased their survival. Yet the clinical course of these infants is complicated by the emergence of opportunistic microbial pathogens. Most importantly, serious infections from opportunistic fungi, such as Candida albicans, have produced systemic disease in vulnerable LBW infants. Invasive C. albicans infection is generally difficult to manage and is associated with high morbidity and mortality. Because the infection has an insidious and rapid course, the critical care nurse and advanced practice nurse need to provide key prevention and early treatment measures. © Williams & Wilkins 1998. All Rights Reserved.