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Gut Microbiota, Atherosclerosis, and Therapeutic Targets

Mantziaris, Vasileios MD*; Kolios, George MD, PhD

doi: 10.1097/HPC.0000000000000187
Review Articles

Several studies have gathered interest in the relationship between gut microbiota and atherosclerosis. Gut microbiota and its metabolites, such as trimethylamine-N-oxide, and gut dysbiosis play an important role in the development of atherosclerosis. Also, inflammation, derived by the intestinal tract, adds another mechanism through which the ecosystem of the human body affects the metabolic diseases and, furthermore, cardiovascular diseases. The scientific world should fixate the understanding of the exact physiologic and pathophysiologic mechanisms for atherogenesis by gut microbiota and through that, new ways for novel therapeutic targets will be available in the coming years. This review summarizes the latest data on this matter.

From the *Department of Clinical Pharmacology and Therapeutics, Medical School, Democritus University of Thrace, Alexandroupolis, Greece

Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.

Received for publication March 1, 2019; accepted April 18, 2019.

Reprints: Vasileios Mantziaris, MD, Lofos Draganas, Alexandroupolis. E-mail:

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