Contrast-induced nephropathy has continued to plague interventional cardiology as an all-too-frequent complication of diagnostic and therapeutic procedures. We present an evidence-based protocol for prevention of this complication that uses infusion of NaHCO3 to effect urinary alkalinization and possibly decrease free-radical renal injury resulting from contrast exposure.
From the *Division of Nephrology, Mayo Clinic, Rochester, Minnesota; †Metrolina Nephrology Associates, Charlotte, North Carolina; the ‡Clinical Pharmacy, Carolinas Medical Center, Charlotte, North Carolina; and the §Department of Internal Medicine and Cannon Research Center, Carolinas Medical Center, Charlotte, North Carolina.
Reprints: Thomas P. Kennedy, MD, MPH, Department of Internal Medicine, Carolinas Medical Center, MEB 507, P.O. Box 32861, Charlotte, NC 28232. E-mail: email@example.com