We aimed to assess the diagnostic importance of serum solubilized adhesion molecules, vascular cell adhesion molecule-1, intercellular adhesion molecule-1, sE-selectin and sP-selectin in aortocoronary saphenous vein graft disease. The study population was composed of two groups consisting of 41 patients with saphenous vein graft stenosis and 43 patients without saphenous vein graft stenosis based on the results of coronary angiography. At the time of cardiac catheterization, it had been more than 1 year since the operation. Serum level of sP-selectin was significantly higher in the stenosis group than in the no-stenosis group. No differences were found between the two groups with respect to serum levels of sE-selectin, intercellular adhesion molecule-1 and vascular cell adhesion molecule-1. Multivariate analysis revealed that only serum levels of sP-selectin, HDL cholesterol and LDL cholesterol were independently correlated with the stenosis of saphenous vein grafts. This study suggests that platelet activation may play a causal role in late graft disease.