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Coffee reduces the risk of death after acute myocardial infarction

a meta-analysis

Brown, Oliver I.; Allgar, Victoria; Wong, Kenneth Y.-K.

doi: 10.1097/MCA.0000000000000397
Original Research

Background Habitual coffee consumption is protective against coronary heart disease in women; however, it is not clear whether such cardioprotection is conferred on those who have already experienced an acute myocardial infarction (AMI). Our aim was to investigate whether coffee consumption affected mortality after AMI.

Materials and methods We carried out a dose–response meta-analysis of prospective studies that examined the relationship between coffee intake and mortality after an AMI. Using a defined-search strategy, electronic databases (MEDLINE and Embase) were searched for papers published between 1946 and 2015. Two eligible studies investigating post-AMI mortality risk against coffee consumption were identified and assessed using set criteria. Combined, these studies recruited a total of 3271 patients and 604 died. The hazard ratios for the following experimental groups were defined: light coffee drinkers (1–2 cups/day) versus noncoffee drinkers, heavy coffee drinkers (>2 cups/day) versus noncoffee drinkers and heavy coffee drinkers versus light coffee drinkers.

Results A statistically significant inverse correlation was observed between coffee drinking and mortality; all three groups showed a significant reduction in risk ratio. Light coffee drinkers versus noncoffee drinkers were associated with a risk ratio of 0.79 [95% confidence interval (CI): 0.66–0.94, P=0.008]; heavy coffee drinkers versus noncoffee drinkers were associated with a risk ratio of 0.54 (95% CI: 0.45–0.65, P<0.00001); and heavy coffee drinkers versus light coffee drinkers were associated with a risk ratio of 0.69 (95% CI: 0.58–0.83, P<0.0001).

Conclusion Drinking coffee habitually following AMI was associated with a reduced risk of mortality.

aDepartment of Academic Cardiology, Castle Hill Hospital, Kingston upon Hull

bDepartment of Health Sciences, University of York, York, UK

Correspondence to Oliver I. Brown, Department of Academic Cardiology, Hull and East Yorkshire Medical Research and Teaching Centre (Daisy Building), Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire HU16 5JQ, UK Tel: +44 799 999 3411; fax: +44 148 246 1779; e-mail:

Received February 10, 2016

Received in revised form April 28, 2016

Accepted May 18, 2016

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