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Utility of mean platelet volume to predict the prevalence of coronary artery disease on coronary angiography in patients with stable angina

Lin, Yangyi*; Chen, Xia*; Xu, Xiangdong

doi: 10.1097/MCA.0000000000000747
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Background Approximately 50% of patients with stable angina have coronary artery disease (CAD) on coronary angiography. The mean platelet volume (MPV) has been proposed as a marker that reflects platelet size and reactivity. This study investigated the predictive value of high MPV in patients with stable angina for diagnosing stable CAD.

Patients and methods A total of 491 patients with chest pain who underwent selective coronary angiography for suspected CAD were enrolled. The patients were divided into the CAD group and non-CAD group according to angiography. All demographic, laboratory, and angiographic data were collected.

Results Patients with MPV in the highest tertile were more likely to have CAD (66.9 vs. 51.0 vs. 35.7% for the highest, middle, and lowest tertiles; P=0.001), had lower platelet counts (186±48 vs. 199±52 vs. 223±63; P<0.001), and had higher hemoglobin A1c levels (6.8±1.5 vs. 6.5±1.5 vs. 6.2±1.1; P<0.001). MPV had a positive correlation with hemoglobin A1c (r=0.16; P<0.001). Patients with CAD (n=248) had higher MPV than those without CAD (n=243) (11.0±1.0 vs. 10.5±0.9; P<0.001). MPV was an independent predictor of CAD in patients with stable angina, with an adjusted odds ratio of 1.820 (95% confidence interval: 1.453–2.279; P<0.001).

Conclusion The presence of high MPV predicts the prevalence of CAD on coronary angiography in patients with stable angina, and this result may ultimately reduce unnecessary invasive coronary angiography.

Department of Cardiology, Jiading District Central Hospital Affiliated Shanghai University of Medical and Health Sciences, Shanghai, China

* Yangyi Lin and Xia Chen contributed equally to the writing of this article.

Correspondence to Xiangdong Xu, MD, Department of Cardiology, Jiading District Central Hospital Affiliated Shanghai University of Medical and Health Sciences, Shanghai 200018, China Tel: +86 216 607 3213; fax: +86 216 607 3325; e-mail: xuxiangdong8416@163.com

Received January 12, 2019

Received in revised form February 1, 2019

Accepted March 24, 2019

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