Secondary Logo

Journal Logo

Association between circulating big endothelin-1 and noncalcified or mixed coronary atherosclerotic plaques

Wang, Fanga; Li, Tieweia; Cong, Xiangfenga; Hou, Zhihuib; Lu, Binb; Zhou, Zhoua; Chen, Xia

doi: 10.1097/MCA.0000000000000752
Original research: PDF Only

Background Noncalcified plaques (NCPs) and mixed plaques (MPs) are considered as the high-risk coronary plaques. Endothelin-1 (ET-1) is a vasoactive peptide and shows a high expression in vulnerable plaque. The aim of this study is to investigate the relationship between the bigET-1, the precursor of ET-1, and NCPs/MPs in a Chinese population.

Methods and results A total of 513 patients with chest pain and suspected coronary artery disease were collected and divided into three groups with no plaques, calcified plaques, or NCPs/MPs according to the characteristics of all the plaques. It demonstrated that NCPs/MPs were associated with elevated bigET-1 (P<0.001). Moreover, the proportion of NCPs/MPs was significantly increased from 43.3% in bigET-1 tertile 1 to 61.0% in tertile 3 group (P=0.001). Multiple logistic regression analysis further showed that bigET-1 was an independent predictor for the presence of NCPs/MPs (odds ratio=1.858; 95% confidence interval: 1.017–3.394; P=0.044).

Conclusion The bigET-1 could be an independent predictor for the presence of NCPs/MPs.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

aState Key Laboratory of Cardiovascular Disease, Center of Laboratory Medicine, Fuwai Hospital

bState Key Laboratory of Cardiovascular Disease, Department of Radiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China

Correspondence to Xi Chen, PhD, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, No. 167 Bei Li Shi Street, Xi-Cheng District, Beijing 100037, China Tel: +86 108 839 8584; fax: +86 108 839 6050; e-mail:

Received October 23, 2018

Received in revised form January 20, 2019

Accepted March 22, 2019

Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.