Noncalcified plaques (NCPs) and mixed plaques (MPs) are considered as the high-risk coronary plaques. Endothelin-1 (ET-1) is a vasoactive peptide and shows a high expression in vulnerable plaque. The aim of this study is to investigate the relationship between the bigET-1, the precursor of ET-1, and NCPs/MPs in a Chinese population.
A total of 513 patients with chest pain and suspected coronary artery disease were collected and divided into three groups with no plaques, calcified plaques, or NCPs/MPs according to the characteristics of all the plaques. It demonstrated that NCPs/MPs were associated with elevated bigET-1 (P<0.001). Moreover, the proportion of NCPs/MPs was significantly increased from 43.3% in bigET-1 tertile 1 to 61.0% in tertile 3 group (P=0.001). Multiple logistic regression analysis further showed that bigET-1 was an independent predictor for the presence of NCPs/MPs (odds ratio=1.858; 95% confidence interval: 1.017–3.394; P=0.044).
The bigET-1 could be an independent predictor for the presence of NCPs/MPs.
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aState Key Laboratory of Cardiovascular Disease, Center of Laboratory Medicine, Fuwai Hospital
bState Key Laboratory of Cardiovascular Disease, Department of Radiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
Correspondence to Xi Chen, PhD, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, No. 167 Bei Li Shi Street, Xi-Cheng District, Beijing 100037, China Tel: +86 108 839 8584; fax: +86 108 839 6050; e-mail: email@example.com
Received October 23, 2018
Received in revised form January 20, 2019
Accepted March 22, 2019