To determine whether transradial access (TRA) is as safe and efficacious as transfemoral access (TFA) in patients undergoing left main percutaneous coronary intervention (PCI).
A systematic search of Medline, Embase, and the Cochrane Central Register of Controlled Trials databases was performed to indentify studies comparing TRA with TFA in left main PCI. The primary efficacy outcome was the incidence of major adverse cardiac events (MACEs) and the primary safety outcome was bleeding.
Our systematic search identified eight nonrandomized studies including 2858 patients. The risk of MACEs was similar between TFA and TRA [unadjusted data: risk ratio (RR): 0.89; 95% confidence interval (CI): 0.71–1.10; P=0.27; propensity score matched data: RR: 0.97; 95% CI: 0.94–1.28; P=0.63], but PCI with TRA was associated with a significantly lower risk of bleeding (RR: 0.28; 95% CI: 0.17–0.47; P<0.001). The risks of death, cardiac death, myocardial infarction, and target vessel revascularization were similar between the TRA and TFA groups, except for target lesion revascularization, which was lower in the TRA group.
In patients undergoing left main PCI, TRA was comparable to TFA in terms of MACEs, but was associated with a lower risk of bleeding. These results indicate that TRA could be the first choice for left main PCI in selected populations.
Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
Correspondence to Yong Zeng, MD, Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, No. 2, Anzhen Road, Chaoyang District, Beijing 100029, China Tel/fax: +86 106 445 6371; e-mail: email@example.com
Received August 25, 2018
Received in revised form November 9, 2018
Accepted November 16, 2018