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Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study

rationale and design

Nakanishi, Rinea; Post, Wendy S.c,e; Osawa, Kazuhiroa; Jayawardena, Eranthia; Kim, Michaela; Sheidaee, Nasima; Nezarat, Negina; Rahmani, Sinaa; Kim, Nicholasa; Hathiramani, Nicolaia; Susarla, Shriraja; Palella, Frankf; Witt, Malloryb; Blaha, Michael J.c,d; Brown, Todd T.d; Kingsley, Lawrenceg,h; Haberlen, Sabina A.e; Dailing, Christophera; Budoff, Matthew J.a

doi: 10.1097/MCA.0000000000000546
Original Research

Background and aim The association of HIV with coronary atherosclerosis has been established; however, the progression of coronary atherosclerosis over time among participants with HIV is not well known. The Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study is a large prospective multicenter study quantifying progression of coronary plaque assessed by serial coronary computed tomography angiography (CTA).

Patients and methods HIV-infected and uninfected men who were enrolled in the Multicenter AIDS Cohort Study Cardiovascular Substudy were eligible to complete a follow-up contrast coronary CTA 3–6 years after baseline. We measured coronary plaque volume and characteristics (calcified and noncalcified plaque including fibrous, fibrous-fatty, and low attenuation) and vulnerable plaque among HIV-infected and uninfected men using semiautomated plaque software to investigate the progression of coronary atherosclerosis over time.

Conclusion We describe a novel, large prospective multicenter study investigating incidence, transition of characteristics, and progression in coronary atherosclerosis quantitatively assessed by serial coronary CTAs among HIV-infected and uninfected men.

aDepartment of Cardiology, Los Angeles Biomedical Research Institute

bDepartment of HIV Medicine, Harbor–UCLA Medical Center, Torrance, California

cDepartment of Medicine, Division of Cardiology, Johns Hopkins Ciccarone Center for the Prevention of Heart Disease

dDepartment of Endocrinology, Johns Hopkins School of Medicine

eDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland

fDepartment of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois

Departments of gInfectious Diseases and Microbiology

hEpidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Correspondence to Matthew J. Budoff, MD, Department of Cardiology, Los Angeles Biomedical Research Institute at Harbor–UCLA, 1124 W Carson Street, Torrance, CA 90502, USA Tel: +1 424 201 3000; fax: +1 310 782 9652; e-mail:

Received April 28, 2017

Received in revised form July 5, 2017

Accepted July 12, 2017

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