The association of HIV with coronary atherosclerosis has been established; however, the progression of coronary atherosclerosis over time among participants with HIV is not well known. The Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study is a large prospective multicenter study quantifying progression of coronary plaque assessed by serial coronary computed tomography angiography (CTA).
HIV-infected and uninfected men who were enrolled in the Multicenter AIDS Cohort Study Cardiovascular Substudy were eligible to complete a follow-up contrast coronary CTA 3–6 years after baseline. We measured coronary plaque volume and characteristics (calcified and noncalcified plaque including fibrous, fibrous-fatty, and low attenuation) and vulnerable plaque among HIV-infected and uninfected men using semiautomated plaque software to investigate the progression of coronary atherosclerosis over time.
We describe a novel, large prospective multicenter study investigating incidence, transition of characteristics, and progression in coronary atherosclerosis quantitatively assessed by serial coronary CTAs among HIV-infected and uninfected men.
aDepartment of Cardiology, Los Angeles Biomedical Research Institute
bDepartment of HIV Medicine, Harbor–UCLA Medical Center, Torrance, California
cDepartment of Medicine, Division of Cardiology, Johns Hopkins Ciccarone Center for the Prevention of Heart Disease
dDepartment of Endocrinology, Johns Hopkins School of Medicine
eDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland
fDepartment of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois
Departments of gInfectious Diseases and Microbiology
hEpidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Correspondence to Matthew J. Budoff, MD, Department of Cardiology, Los Angeles Biomedical Research Institute at Harbor–UCLA, 1124 W Carson Street, Torrance, CA 90502, USA Tel: +1 424 201 3000; fax: +1 310 782 9652; e-mail: firstname.lastname@example.org
Received April 28, 2017
Received in revised form July 5, 2017
Accepted July 12, 2017