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2DS2-VASc score">CHA2DS2-VASc score and exercise capacity of patients with coronary artery disease participating in cardiac rehabilitation programs

Haskiah, Ferasa; Shacham, Yacovb,c; Minha, Saard; Rozenbaum, Zachb,c; Pereg, Davidc,e

doi: 10.1097/MCA.0000000000000550
Original Research

Background Exercise based cardiac rehabilitation improves prognosis and quality of life in patients with coronary artery disease. We aimed to investigate whether the 2DS2-VASc score">CHA2DS2-VASc score may be a predictor of improvement in exercise capacity in acute coronary syndrome (ACS) patients participating in a cardiac rehabilitation program.

Methods Included were patients following a hospital admission due to ACS and were subsequently referred for an exercise based cardiac rehabilitation during 2010–2015. Participants were divided into three groups of low (1–2), intermediate (3) and high (4≤) 2DS2-VASc score">CHA2DS2-VASc score. Exercise capacity was evaluated by a treadmill stress test at baseline and following 9 months. The primary endpoint was the percent of patients who achieved at least 25% improvement in exercise capacity.

Results The 597 patients included in the study had a mean age of 65.5±9.3 years and consisted of 22.5% women. The primary endpoint of at least 25% improvement in exercise capacity following 9 months of cardiac rehabilitation occurred more frequently in patients in the high CHA2DS2-VASc group compared to the intermediate and low 2DS2-VASc score">CHA2DS2-VASc score groups (47.3, 29.9 and 36.1% in the high, intermediate and low 2DS2-VASc score">CHA2DS2-VASc score groups respectively, P=0.002).

Conclusion The 2DS2-VASc score">CHA2DS2-VASc score may serve as a predictor of exercise capacity improvement. Its use for tailoring specific cardiac rehabilitation programs for ACS patients may yield further improvement in functional capacity and better utilization of resources.

aHadassah-Hebrew University Medical Centre, Jerusalem

bDepartment of Cardiology, Tel Aviv Sourasky Medical Center

cSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

dCardiology Department, Assaf-Harofeh Medical Center, Zerifin

eDepartment of Cardiology, Meir Medical Center, Kfar Saba, Israel

Correspondence to David Pereg, MD, Cardiology Division, Meir Medical Center, 59 Tchernichovsky Street, Kfar Saba 44281, Israel Tel: 972 9747 2587; fax: +972 9747 2812; e-mail:

Received July 6, 2017

Received in revised form July 26, 2017

Accepted July 27, 2017

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