Increased arterial stiffness is an independent risk factor for cardiovascular disease. Arterial stiffness is higher in obese individuals than in nonobese individuals. Lifestyle modifications (i.e. exercise and dietary modification) decrease arterial stiffness in obese individuals. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase, an enzyme responsible for the generation of nitric oxide.
The aim of this study was to examine whether lifestyle modifications affect circulating levels of ADMA in overweight and obese men and, if they do, whether ADMA is involved in the mechanism underlying the decrease in arterial stiffness with lifestyle modification.
Seventeen overweight and obese men (BMI: 29.8±0.8 kg/m2) completed a 12-week lifestyle modification program, which included aerobic exercise and dietary modification. Before and after the intervention, we evaluated brachial-ankle pulse wave velocity (baPWV), an index of arterial stiffness, and plasma ADMA concentration in all participants.
After the 12-week lifestyle modification program, BMI and baPWV decreased significantly and the plasma ADMA concentration decreased markedly in overweight and obese men. There was a significant positive correlation between percent change in baPWV and plasma ADMA concentration.
Lifestyle modifications reduce arterial stiffness and plasma ADMA concentration in overweight and obese individuals. A decrease in arterial stiffness was associated with a corresponding reduction in plasma ADMA concentrations. These results suggest that reductions in ADMA may be an important mechanism underlying the beneficial effect of lifestyle modification on arterial stiffness.
aFaculty of Health and Sport Sciences
bFaculty of Medicine
cGraduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
Correspondence to Seiji Maeda, PhD, Division of Sports Medicine, Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8574, Japan Tel: +81 29 853 2683; fax: +81 29 853 2986; e-mail: email@example.com
Received April 8, 2013
Accepted June 22, 2013