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Lifestyle modification decreases arterial stiffness and plasma asymmetric dimethylarginine level in overweight and obese men

Maeda, Seiji; Miyaki, Asako; Kumagai, Hiroshi; Eto, Miki; So, Rina; Tanaka, Kiyoji; Ajisaka, Ryuichi

doi: 10.1097/MCA.0b013e3283647a99
Original Research
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Background Increased arterial stiffness is an independent risk factor for cardiovascular disease. Arterial stiffness is higher in obese individuals than in nonobese individuals. Lifestyle modifications (i.e. exercise and dietary modification) decrease arterial stiffness in obese individuals. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase, an enzyme responsible for the generation of nitric oxide.

Aim The aim of this study was to examine whether lifestyle modifications affect circulating levels of ADMA in overweight and obese men and, if they do, whether ADMA is involved in the mechanism underlying the decrease in arterial stiffness with lifestyle modification.

Methods Seventeen overweight and obese men (BMI: 29.8±0.8 kg/m2) completed a 12-week lifestyle modification program, which included aerobic exercise and dietary modification. Before and after the intervention, we evaluated brachial-ankle pulse wave velocity (baPWV), an index of arterial stiffness, and plasma ADMA concentration in all participants.

Results After the 12-week lifestyle modification program, BMI and baPWV decreased significantly and the plasma ADMA concentration decreased markedly in overweight and obese men. There was a significant positive correlation between percent change in baPWV and plasma ADMA concentration.

Conclusion Lifestyle modifications reduce arterial stiffness and plasma ADMA concentration in overweight and obese individuals. A decrease in arterial stiffness was associated with a corresponding reduction in plasma ADMA concentrations. These results suggest that reductions in ADMA may be an important mechanism underlying the beneficial effect of lifestyle modification on arterial stiffness.

aFaculty of Health and Sport Sciences

bFaculty of Medicine

cGraduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan

Correspondence to Seiji Maeda, PhD, Division of Sports Medicine, Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8574, Japan Tel: +81 29 853 2683; fax: +81 29 853 2986; e-mail: maeda@taiiku.tsukuba.ac.jp

Received April 8, 2013

Accepted June 22, 2013

Copyright © 2013 Wolters Kluwer Health, Inc. All rights reserved.