Original ArticlesEpidemiology of the diabetic heartTziakas, Dimitrios N.a; Chalikias, Georgios K.a; Kaski, Juan CarlosbAuthor Information aUniversity Cardiology Department, Democritus University of Thrace, Alexandroupolis, Greece bCardiovascular Biology Research Centre, Division of Cardiac and Vascular Sciences, St George's, University of London, London, UK Correspondence and requests for reprints to Professor Juan Carlos Kaski, Cardiovascular Biology Research Centre, Division of Cardiac and Vascular Sciences, St. George's, University of London, Cranmer Terrace, London SW17 0RE, UK Tel: +44 208 725 3963; fax +44 208 725 3328; e-mail: [email protected] Coronary Artery Disease: November 2005 - Volume 16 - Issue - p S3-S10 Buy Abstract Diabetes mellitus is a worldwide epidemic. Cardiovascular disease remains the major cause of morbidity and mortality in people with diabetes. Studies have suggested that increased risk of cardiovascular disease is not restricted to type II or type I diabetes mellitus, but extends to prediabetic stages such as impaired fasting glucose, impaired glucose tolerance, metabolic syndrome, and obesity. Insulin resistance, impaired fasting glucose, impaired glucose tolerance, and diabetes mellitus form a continuous sequence of risk for cardiovascular disease. Therefore, cardiovascular disease mortality and morbidity within the diabetes epidemic grow into vast proportions. Evidence also exists that diabetic patients have a high prevalence of heart failure or impaired diastolic and systolic cardiac function subsequent to the combination of coronary artery disease, hypertension, and diabetic cardiomyopathy. In view of the proportions of this new epidemic, prevention of diabetes and its prediabetic states is likely to be the most effective strategy to prevent serious cardiovascular events. © 2005 Lippincott Williams & Wilkins, Inc.