Reviews in DepthPrevention of restenosis after stenting: the emerging role of inflammationVersaci, Francescoa; Gaspardone, AchillebAuthor Information aCattedra di Cardiochirurgia, Università di Roma Tor Vergata, Rome bDivisione di Cardiologia, Ospedale S. Eugenio, Rome, Italy Conflicts of interest: none Correspondence and requests for reprints to: Francesco Versaci, MD, Divisione di Cardiochirurgia, Università di Roma Tor Vergata, European Hospital, via Portuense 700, 00149 Rome, Italy Tel: +39 06 6597 5608; fax: +39 06 6597 5724; e-mail: [email protected] Coronary Artery Disease: September 2004 - Volume 15 - Issue 6 - p 307-311 Buy Abstract Restenosis after stent implantation is mainly caused by neointimal proliferation through the stent struts. Experimental studies indicate a marked activation of inflammatory cells at the site of stent struts, which are likely to play a key role in the process of neointimal proliferation and restenosis. Coronary stenting is a strong inflammatory stimulus and the acute systemic inflammatory response to local inflammation produced by coronary stenting is highly individual and predicts restenosis and event-free survival. The benefit of anti-inflammatory therapy during the periprocedural period and long-term follow-up is dependent on the inflammatory status. Measurement of cytokine and acute phase proteins, such as C-reactive protein, may be important to identify high-risk subjects and develop specific treatment tailored to the individual patient. © 2004 Lippincott Williams & Wilkins, Inc.