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Allicin-induced decrease in formation of fatty streaks (atherosclerosis) in mice fed a cholesterol-rich diet

Abramovitz Dana; Gavri, Sagui; Harats, Dror; Levkovitz, Hanna; Mirelman, David; Miron, Talia; Eilat-Adar, Sigal; Rabinkov, Aharon; Wilchek, Meir; Eldar, Michael; Vered, Zvi
Coronary Artery Disease: 1999
THERAPY AND PREVENTION: PDF Only

Background

Garlic (Allium sativum) has been considered to exhibit therapeutic features for many years. The effects of garlic on levels of serum lipids and on atherosclerosis have been investigated extensively. We have previously demonstrated that allicin, an active component of garlic, exerts a beneficial effect on lipid profile in hyperlipidemic rabbits.

Objective

To investigate the effects of allicin on formation of fatty streaks (atherosclerosis) and lipid profile in mice.

Methods

Allicin was extracted from garlic and kept in a buffer citrate solution at 4°C. Sixty C57BL/6 mice were fed Paigen diet (17% fat, 1.25% cholesterol) for 15 weeks. Thirty randomly selected animals were administered allicin solution (9mg/kg) and 30 were administered placebo. Blood lipid profile was evaluated five times during the study. At the end of the 15-week period, the animals were killed and the aortic sinus was evaluated for formation of fatty streaks (atherosclerosis).

Results

We observed no statistically significant differences between blood lipid profiles of groups. Microscopic evaluation of aortic sinus formation of fatty streaks (atherosclerosis), however, showed that values for mice in the allicin-treated group were significantly lower: areas of formation of fatty streaks (atherosclerosis) were 13440±3310 and 23410±3723 μm2, respectively, for allicin-treated and control mice (means±SEM; P = 0.023).

Conclusions

These results indicate that allicin reduces formation of fatty streaks (atherosclerosis) in hyperlipidemic mice. These changes do not seem to occur through an alteration in blood lipid profile. Coronary Artery Dis 10:515–519

© 1999 Lippincott Williams & Wilkins, Inc.