REVIEW IN DEPTH: PDF OnlyPremature atherosclerosis and familial hypercholesterolemiaSchieken, Richard MDAuthor Information Department of Pediatrics, Children's Medical Center, Richmond, VA, USA. Coronary Artery Disease: February 1993 - Volume 4 - Issue 2 - p 126-132 Buy Abstract Recently, there has been a major emphasis on screening children and adolescents to determine their risk for the future development of atherosclerosis. These studies have resulted in both newer algorithms and newer techniques for identifying risks. The apolipoproteins have featured prominently in the search for newer and more selective tests to identify risk. The molecular genetic techniques are now combined with epidemiologic studies to uncover unrecognized abnormalities that may cause premature atherosclerosis. In addition, the effects of commonly used drugs, such as oral contraceptives, are recognized as modifying risk factors. Newer strategies have been developed to counter the adverse effects of the older formulations of oral contraceptives. © Lippincott-Raven Publishers.