To evaluate 3-dimensional epithelial remodeling in patients undergoing myopic laser in situ keratomileusis (LASIK) versus small incision lenticule extraction (SMILE).
In a prospective randomized contralateral eye study of LASIK versus SMILE procedures, 21 consecutive patients (42 eyes) were evaluated with corneal epithelial mapping by anterior segment optical coherence tomography for up to 2 years.
In the LASIK group, central epithelial thickness increased from 52.38 ± 2.57 μm to 57.00 ± 4.23 μm and remained almost stable at this level for up to 24 months. In the SMILE eyes, it increased from 52.52 ± 3.01 μm to 57.15 ± 4.57 μm and also remained stable for up to 24 months. Both techniques created the same level of epithelial thickness increase and variation, with a significantly higher mid-peripheral epithelial thickness increase. The differences between the preoperative and postoperative changes were found statistically significant, but not different between the 2 techniques at any given time studied.
Both LASIK and SMILE resulted in significant epithelial thickening. This response seemed to be surprisingly quite similar between the 2 different techniques. This study suggests that epithelial remodeling may correlate with relative curvature changes resulting after both techniques, rather than the obvious difference of subepithelial corneal denervation changes.
*Laservision.gr Clinical and Research Eye Institute, Athens, Greece; and
†Department of Ophthalmology, New York University Medical School, New York, NY.
Correspondence: Anastasios J. Kanellopoulos, MD, Laservision.gr Clinical and Research Eye Institute, LaserVision.gr, Tsocha St 17, Athens 115 21, Greece (e-mail: firstname.lastname@example.org).
A. J. Kanellopoulos is a consultant for Alcon, Avedro, Allergan, i-Optics, Keramed, Zeiss, and ISP Surgical.
Received June 14, 2018
Accepted October 06, 2018