Clinical ScienceClinical Outcomes and Patient Satisfaction After Corneal NeurotizationRafailov, Leon MD*; Kim, Jane S. MD†; Wisely, Clayton Ellis MD, MBA†; Espana, Edgar M. MD‡; Soifer, Matias MD§; Leyngold, Ilya M. MD*Author Information *Division of Oculoplastic Surgery, Department of Ophthalmology, Duke University Medical Center, Durham, NC; †Department of Ophthalmology, Duke University Medical Center, Durham, NC; ‡Cornea and External Disease, Department of Ophthalmology, University of South Florida Morsani College of Medicine, Tampa, FL; and §Foster Center for Ocular Immunology, Duke University Medical Center, Durham, NC Correspondence: Ilya M. Leyngold, MD, Division of Oculoplastic Surgery, Department of Ophthalmology, Duke University Medical Center, 2351 Erwin Rd, Durham, NC 27705 (e-mail: [email protected]). I. M. Leyngold is a consultant for AxoGen Inc. The remaining authors have no conflicts of interest to disclose. Cornea: November 2021 - Volume 40 - Issue 11 - p 1377-1386 doi: 10.1097/ICO.0000000000002759 Buy Metrics Abstract Purpose: The aim of this study was to assess clinical outcomes of corneal neurotization (CN) and determine patient perception of postoperative results. Methods: This was a retrospective study involving 29 eyes in 28 patients who underwent CN. Chart review data included demographic and clinical history; ophthalmic examination including visual acuity, ocular surface quality, and corneal sensation; surgical technique; and postoperative course. Subjective self-reported patient outcomes of surgical success were also assessed. Only eyes with at least 6 months of follow-up were included in the statistical analysis. Results: A total of 24 eyes and 23 patients were included in statistical analyses. The median postoperative follow-up time was 12.2 months (interquartile range 10.9–18.5 mo). Twenty-three eyes (92%) achieved improvement in ocular surface quality. Eleven of 13 (85%) demonstrated healing of persistent epithelial defects at their last follow-up. Patients gained a median of 2.3 cm in Cochet–Bonnet esthesiometry measurements of sensation. No significant difference was found between preoperative and postoperative visual acuity. All 17 patients who provided self-assessment of their surgical outcome indicated they would undergo CN again if given the choice. Most of the patients reported that the postoperative pain was tolerable, with a median pain score of 3.0 on a 10-point scale (interquartile range 0.0–4.0). Sixteen patients (94%) reported full or partial return of skin sensation along the donor nerve distribution. Conclusions: CN provides improvement in corneal health and sensibility, with high patient satisfaction and minimal postoperative pain and morbidity. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.