ReviewEye Banking: One Cornea for Multiple RecipientsGadhvi, Kunal A. MBBS, FRCOphth*; Coco, Giulia MD*; Pagano, Luca MD*; Kaye, Stephen B. MD, FRCS, FRCOphth*,†; Ferrari, Stefano PhD‡; Levis, Hannah J. PhD†; Parekh, Mohit PhD§; Romano, Vito MD*,†Author Information *St. Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, United Kingdom; †Department of Eye and Vision Science, University of Liverpool, Liverpool, United Kingdom; ‡International Center for Ocular Physiopathology, Fondazione Banca degli Occhi del Veneto Onlus, Venice, Italy; and §Institute of Ophthalmology, University College London, London, United Kingdom. Correspondence: Vito Romano, MD, Department of Corneal and External Eye Diseases, St Paul's Eye Unit, Royal Liverpool University Hospital, Prescot St, L78XP Liverpool, United Kingdom (e-mail: [email protected]). The authors have no funding or conflicts of interest to disclose Cornea: December 2020 - Volume 39 - Issue 12 - p 1599-1603 doi: 10.1097/ICO.0000000000002476 Buy Metrics Abstract Purpose: Corneal transplantation is the most frequently performed transplant procedure. In much of the world, the demand for donor tissue heavily outstrips supply. With developments within lamellar corneal graft surgery, the use of split corneal donor tissue to increase donor tissue supply seems a pragmatic solution to reduce the supply and demand mismatch. This is especially important with tissue supply expected to be affected by the COVID-19 pandemic. Methods: A literature review of techniques was performed, enabling multiple transplants to be derived from a single donor and simulation of a model to quantify the number of corneas potentially saved. Results: Studies on splitting corneal donor tissue have demonstrated that up to 5 recipients may benefit from 1 donor scleral button. The impact of splitting donor tissue may provide a saving of up to 25.3% of donor graft tissue. Conclusions: Splitting and preparing the donor tissue within an eye bank will improve tissue validation and donor tissue availability and may increase surgeon efficiency. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.