Transferability of an Artificial Intelligence Algorithm Predicting Rebubblings After Descemet Membrane Endothelial Keratoplasty : Cornea

Secondary Logo

Journal Logo

Clinical Science

Transferability of an Artificial Intelligence Algorithm Predicting Rebubblings After Descemet Membrane Endothelial Keratoplasty

Hayashi, Takahiko MD, PhD*; Iliasian, Rosa M.; Matthaei, Mario MD, PhD; Schrittenlocher, Silvia MD; Masumoto, Hiroki MD; Tanabe, Mao MD§; Tabuchi, Hitoshi MD, PhD, EMBA; Siggel, Robert MD; Bachmann, Björn MD, PhD; Cursiefen, Claus MD, PhD; Siebelmann, Sebastian MD, PhD, MHBA†,**,††

Author Information
Cornea 42(5):p 544-548, May 2023. | DOI: 10.1097/ICO.0000000000003049

Abstract

Purpose: 

To develop an artificial intelligence (AI) algorithm enabling corneal surgeons to predict the probability of rebubbling after Descemet membrane endothelial keratoplasty (DMEK) from images obtained using optical coherence tomography (OCT).

Methods: 

Anterior segment OCT data of patients undergoing DMEK by 2 different DMEK surgeons (C.C. and B.B.; University of Cologne, Cologne, Germany) were extracted from the prospective Cologne DMEK database. An AI algorithm was trained by using a data set of C.C. to detect graft detachments and predict the probability of a rebubbling. The architecture of the AI model used in this study was called EfficientNet. This algorithm was applied to OCT scans of patients, which were operated by B.B. The transferability of this algorithm was analyzed to predict a rebubbling after DMEK.

Results: 

The algorithm reached an area under the curve of 0.875 (95% confidence interval: 0.880–0.929). The cutoff value based on the Youden index was 0.214, and the sensitivity and specificity for this value were 78.9% (67.6%–87.7%) and 78.6% (69.5%–86.1%).

Conclusions: 

The development of AI algorithms allows good transferability to other surgeons reaching a high accuracy in predicting rebubbling after DMEK based on OCT image data.

Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.

You can read the full text of this article if you:

Access through Ovid