Invited SubmissionHerpes Zoster: A Brief Definitive ReviewCohen, Elisabeth J. MD*; Jeng, Bennie H. MD†Author Information *Department of Ophthalmology, NYU Langone Health, New York, NY; and †Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD. Correspondence: Elisabeth J. Cohen, MD, Department of Ophthalmology, NYU Langone Health, 1 Park Avenue, Room 6–663, New York, NY 10016 (e-mail: [email protected]). Supported by NEI/NIH cooperative agreement U10 EY 026869. The authors have no conflicts of interest to disclose. Cornea: August 2021 - Volume 40 - Issue 8 - p 943-949 doi: 10.1097/ICO.0000000000002754 Buy Metrics Abstract This brief definitive review of herpes zoster (HZ) will cover the current state of knowledge and questions that remain to be answered regarding HZ in general and HZ ophthalmicus in particular. A question-and-answer format will be used to address various important topics related to this common and serious disease. Questions to be addressed relate to common misconceptions, contagiousness of infection, unknowns regarding pathogenesis, rising incidence, risk factors and complications, relationship with temporal arteritis, vaccination, and current and future antiviral treatment. In addition, the importance of the Zoster Eye Disease Study to determine the efficacy of suppressive valacyclovir treatment in preventing complications of HZ ophthalmicus and the need to support enrollment will be discussed. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.