Case ReportAnterior Segment Optical Coherence Tomography in Ocular ArgyrosisHe, Xu MD; Simmons, Nathaniel L. MD; Wozniak, Rachel A. F. MD, PhDAuthor Information Department of Ophthalmology, University of Rochester Medical Center, Rochester, NY. Correspondence: Rachel A. F. Wozniak, MD, PhD, Department of Ophthalmology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 659, Rochester, NY 14642 (e-mail: [email protected]). Unrestricted departmental grant from the Research to Prevent Blindness (X. He, N. L. Simmons, R. A. F. Wozniak); NIH K08 award, EYE29012-01 (R. A. F. Wozniak). The authors have no conflicts of interest to disclose. Cornea: November 2020 - Volume 39 - Issue 11 - p 1433-1435 doi: 10.1097/ICO.0000000000002323 Buy Metrics Abstract Purpose: To highlight the novel application of anterior segment optical coherence tomography (AS-OCT) to detect corneal silver deposition in a case of ocular argyrosis. Methods: This is a case report and review of the literature. Results: A 67-year-old man with a 30-year history of chronic occupational exposure to silver-halides secondary to photographic film manufacturing presented with significant ocular argyrosis. His ophthalmic examination was notable for bilateral, widespread pinpoint gray deposits throughout his conjunctiva and cornea at the level of Descemet membrane. Further evaluation with AS-OCT showed deposition in 2 distinct, diffusely hyperreflective bands, corresponding to Bowman layer and Descemet membrane. Conclusions: AS-OCT provides a useful imaging modality in evaluating corneal deposition diseases. In this case of ocular argyrosis, AS-OCT led to the detection of a hyperreflective Bowman layer and Descemet membrane, representing silver deposition in both these anatomic locations. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.