To report the results of penetrating keratoplasty
(PKP) assisted by femtosecond laser
in the treatment of persistent infective keratitis
Seven eyes of 7 patients with diagnosed infective keratitis
were recruited. They showed no improvement on maximal medical therapy for a week. The causative organisms were Pseudomonas aeruginosa
in 3 cases and Fusarium
in 4 cases. All cases underwent femtosecond laser
-assisted PKP with a mushroom-shaped cut. Postoperative antimicrobial medications were continued for 8–12 weeks. Sutures were removed after 6 months. Therapeutic success was defined as eradication of primary infection. Functional success was considered when visual function improves to 20/200 or better.
All 7 eyes underwent femtosecond laser
-assisted PKP. There were no intraoperative complications, and all patients had uneventful recipient cornea separation. Anatomic, therapeutic, and functional success was achieved in all patients. During the 6-month follow-up period, no recurrence of infection was reported. The average preoperative corrected distance visual acuity (CDVA) was 2.07 log of the minimal angle of resolution (LogMAR) ± 0.21, whereas at 6 months postoperatively, the average CDVA was 0.17 LogMAR ± 0.13, with a P
value of 0.00025.
Conclusions: Femtosecond laser
-assisted PKP was found to be an effective method for treating infective keratitis
(particularly that caused by Pseudomonas aeruginosa
) that did not respond to medical treatment. Early surgical intervention before the disease becomes advanced is recommended.