We report a case of neurotrophic keratopathy (NK) arising after surgery for rhabdomyosarcoma of the jaw successfully treated with Cenegermin eye drops (Oxervate; Dompé Farmaceutici, Milan, Italy) in a 3-year-old boy.
At the age of 1 year, the boy underwent surgery for rhabdomyosarcoma of the jaw, followed by radiotherapy. Subsequent NK was initially treated with preservative-free artificial tears, topical combination of dexamethasone 0.1% and netilmicin 0.3% (Netildex; Sifi, Catania, Italy), and moxifloxacin 0.5% (Vigamox; Alcon, Fort Worth, TX), followed by 10 cycles of a topical eye biopolymer containing a poly-carboxymethyl glucose sulfate solution (Cacicol; Theà, Clermont-Ferrand, France) and 4 amniotic membrane transplantations. Keratopathy was recalcitrant to therapy and tissue transplant. Therapy was switched to Cenegermin eye drops 6 times daily for 8 weeks.
Complete healing of the corneal epithelium was achieved at 3 weeks into treatment.
Cenegermin was effective in restoring corneal integrity in this pediatric patient with NK.
Department of Neurosciences, Biomedicine and Movement Sciences, Eye Clinic, University of Verona, Verona, Italy.
Correspondence: Jacopo Bonetto, MD, Department of Neurosciences, Biomedicine and Movement Sciences, Eye Clinic, University of Verona, Policlinico G.B. Rossi, P.le L.A. Scuro 10, Verona 37134, Italy (e-mail: firstname.lastname@example.org).
The authors have no funding or conflicts of interest to disclose.
Received December 08, 2018
Received in revised form June 19, 2019
Accepted July 05, 2019
Online date: August 8, 2019