Clinical ScienceCentral Corneal Thickness in Childhood CataractThau, Avrey BS*; Dawodu, Oseluese MD†; Mireskandari, Kamiar MD‡; Ali, Asim MD, FRCSC‡; Tehrani, Nasrin MD‡; DeBenedictis, Caroline MD§; Bhoiwala, Devang MD*; Aultman, William BA§; Alnabi, Waleed A. MD§; Leiby, Benjamin E. PhD¶; Levin, Alex V. MD, MHSc*,‡Author Information *Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA; †Department of Ophthalmology, University of Benin Teaching Hospital, Benin City, Nigeria; ‡Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, ON, Canada; §Pediatric Ophthalmology and Ocular Genetics, Wills Eye Hospital, Philadelphia, PA; and ¶Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA. Correspondence: Alex V. Levin, MD, MHSc, Pediatric Ophthalmology and Ocular Genetics, Wills Eye Institute, 840 Walnut St, Suite 1210, Philadelphia, PA 19107-5109 (e-mail: [email protected]). Supported in part by the Foerderer Fund (A.V.L., Wills Eye Hospital), the Robison D. Harley, MD Endowed Chair in Pediatric Ophthalmology and Ocular Genetics (A.V.L., Wills Eye Hospital), the Joseph F. Bradway Endowed Research Fellow (A.T., Wills Eye Hospital), and Brandan's Eye Research Fund (Hospital for Sick Children). The authors have no conflicts of interest to disclose. Cornea: August 2019 - Volume 38 - Issue 8 - p 1003-1005 doi: 10.1097/ICO.0000000000001970 Buy Metrics Abstract Purpose: We explored elevated central corneal thickness (CCT) in children with cataracts as possibly reflecting preexisting corneal malformation related to specific cataract morphology. Methods: All children consecutively seen during the study periods who had cataracts and corneal pachymetry as part of their routine care were enrolled at academic centers in large cities of Canada and the United States. Study data collected included age, sex, CCT, and cataract morphology. Differences among cataract morphology groups with respect to mean CCT measurements were evaluated and compared with a historical control thickness of 558 μm. Results: A total of 96 children were enrolled in this study. The average subject age was 5.1 years, and 55 children (57%) were female. The mean CCT value for all subjects was 566.1 μm. There was little evidence to conclude that the cataract morphology groups differed from each other (P = 0.65) or from controls with respect to CCT. Conclusions: In children, CCT is likely independent of cataract morphology. This implies that factors other than preoperative malformation are more likely related to elevated CCT observed in children with aphakia and pseudophakia. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.