Case ReportOcular Surface Stem Cell Transplantation for Treatment of Keratitis–Ichthyosis–Deafness SyndromeCheung, Albert Y. MD*,†; Patel, Sunny MD‡; Kurji, Khaliq H. MD*; Sarnicola, Enrica MD*,§; Eslani, Medi MD*; Govil, Amit MD¶; Holland, Edward J. MD*Author Information *Department of Ophthalmology, Cincinnati Eye Institute, University of Cincinnati, Cincinnati, OH; †Virginia Eye Consultants, Norfolk, VA; ‡University of Cincinnati College of Medicine, Cincinnati, OH; §Clinica degli Occhi Sarnicola, Grosseto, Italy; and ¶Division of Nephrology and Hypertension, University of Cincinnati, Cincinnati, OH. Correspondence: Edward J. Holland, MD, 580 South Loop Rd, Suite 200, Edgewood, KY 41017 (e-mail: [email protected]). E. J. Holland has consulted for Alcon Laboratories, Allergan, Bausch & Lomb, Kala Pharmaceuticals, Mati Pharmaceuticals, Omeros, PRN, Senju Pharmaceuticals, Shire, TearLab, and TearScience. A. Y. Cheung has a research grant from the Eye Bank Association of America. The remaining authors have no conflicts of interest to disclose. Cornea: January 2019 - Volume 38 - Issue 1 - p 123-126 doi: 10.1097/ICO.0000000000001802 Buy Metrics Abstract Purpose: To report our surgical experience with ocular surface stem cell transplantation (OSST) for limbal stem cell deficiency (LSCD) in the setting of keratitis–ichthyosis–deafness (KID) syndrome. Methods: Retrospective interventional case series. Results: We present 5 eyes of 3 patients with KID syndrome that developed LSCD and underwent OSST. Mean follow-up after OSST was 8.3 ± 4.3 years (range 3.4–11.4 years). Two eyes underwent living-related conjunctival limbal allograft (lr-CLAL), and 3 eyes were treated with keratolimbal allograft (KLAL). Four of the 5 eyes underwent subsequent keratoplasty. Both lr-CLAL eyes maintained a stable ocular surface at final follow-up. Conversely, all KLAL eyes developed a failed surface requiring repeat KLAL surgery. Because of multiple failed KLALs, 1 eye underwent placement of a keratoprosthesis. Conclusions: KID syndrome is a rare cause of LSCD. Although OSST can stabilize the surface, long-term treatment of KID syndrome can be challenging. An lr-CLAL may offer further benefit over a KLAL in these eyes because it is HLA- and ABO-matched tissue; it also helps to treat keratoconjunctivitis sicca, often a prominent feature of KID syndrome. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.