Case ReportUnilateral Posterior Interstitial Keratitis as a Clinical Presentation of Herpes Simplex Virus DiseaseFarooq, Asim V. MD*; Paley, Grace L. MD, PhD†; Lubniewski, Anthony J. MD†; Gonzales, John A. MD‡; Margolis, Todd P. MD, PhD†Author Information *Department of Ophthalmology and Visual Science, University of Chicago, Chicago, IL; †Department of Ophthalmology and Visual Sciences, Washington University in St. Louis, St. Louis, MO; and ‡Francis I. Proctor Foundation, University of California San Francisco, San Francisco, CA. Correspondence: Todd P. Margolis, MD, PhD, Alan A. and Edith L. Wolff Distinguished Professor and Chairman, Department of Ophthalmology and Visual Sciences, Washington University in St. Louis, 4921 Parkview Place, St. Louis, MO 63110 (e-mail: [email protected]). Supported in part by an unrestricted grant from Research To Prevent Blindness to the Department of Ophthalmology and Visual Sciences at Washington University. The funding organization had no role in the design or conduct of this research. The authors have no conflicts of interest to disclose. A. V. Farooq and G. L. Paley are co-first authors. Cornea: March 2018 - Volume 37 - Issue 3 - p 375-378 doi: 10.1097/ICO.0000000000001499 Buy Metrics Abstract Purpose: To describe a case series of patients with unilateral, posterior interstitial keratitis presumed to be caused by herpes simplex virus. Methods: Retrospective case series. Results: Five patients were found to have unilateral, posterior interstitial keratitis. Three of the involved eyes had decreased corneal sensation, and 2 eyes had corneal stromal neovascularization. All patients were treated with topical steroids and an oral antiviral, and among those with long-term follow-up, clinical improvement required treatment over an extended duration. A review of the literature revealed 1 reported case with a similar clinical appearance, although that case was attributed to Lyme disease. Conclusions: The clinical presentation of unilateral, posterior interstitial keratitis may be a rare manifestation of herpes simplex virus keratitis. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.