Clinical ScienceValidity of Postmortem Glycated Hemoglobin to Determine Status of Diabetes Mellitus in Corneal DonorsSoper, Mark C. BS, CEBT*; Marcovina, Santica M. PhD, DSc†; Hoover, Caroline K. MBA, CEBT‡; Calhoun, Peter M. MA§; McCoy, Kristen E. CEBT, CTBS¶; Stoeger, Christopher G. MBA, CEBT‖; Schmidt, Gregory A. BS, CEBT**; Arafah, Baha M. MD††; Price, Marianne O. PhD‡‡; Szczotka-Flynn, Loretta B. OD, PhD‡‡,§§,¶¶; Lass, Jonathan H. MD§§,¶¶,‖‖ Author Information *Indiana Lions Eye Bank, Indianapolis, IN; †Department of Medicine, University of Washington and the Northwest Lipid Metabolism and Diabetes Research Laboratories, Seattle, WA; ‡SightLife, Seattle, WA; §Jaeb Center for Health Research, Tampa, FL; ¶Eversight Illinois, Chicago, IL; ‖Lions VisionGift, Portland, OR; **Iowa Lions Eye Bank, Iowa City, IA; ††Department of Medicine, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, OH; ‡‡Cornea Research Foundation of America, Indianapolis, IN; §§University Hospitals Eye Institute, Cleveland, OH; ¶¶Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH; and ‖‖Eversight Ohio, Cleveland, OH. Reprints: Jonathan H. Lass, MD, University Hospitals Cleveland Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106 (e-mail: [email protected]). Supported by Research to Prevent Blindness, Inc. (J.H.L.). The authors have no conflicts of interest to disclose. Cornea: August 2017 - Volume 36 - Issue 8 - p 942-947 doi: 10.1097/ICO.0000000000001211 Buy Metrics Abstract Purpose: To examine the stability of postmortem glycated hemoglobin (HbA1c) measurement and its relationship to premortem glycemia. Methods: Postmortem blood samples were obtained from 32 donors (8 known diabetic) and shipped on ice to a central laboratory to examine the stability of HbA1c measurements during the first 9 postmortem days. Thirty-nine other suspected diabetic donors underwent comparison of premortem and postmortem HbA1c measurements. Results: Postmortem HbA1c measurements remained stable after 9 postmortem days (all measurements within ±0.2% from baseline with a mean difference of 0.02% ± 0.10%). Of the premortem measurements obtained within 90 days before death, 79% were within ±1.0% of the postmortem measurements compared with 40% for measurements more than 90 days apart. Three of the postmortem HbA1c measurements exceeded 6.5% (considered a threshold for diabetes diagnosis), although the medical histories did not indicate any previous diabetes diagnosis. Conclusions: Postmortem HbA1c testing is feasible with current eye bank procedures and is reflective of glycemic control of donors during 90 days before death. HbA1c testing could potentially be a useful adjunct to review of the medical history and records for donor assessment for endothelial keratoplasty suitability and long-term graft success. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.