Inflammatory bowel disease may be associated with extraintestinal manifestations. We report a case of severe reactive epithelial atypia resembling ocular surface squamous neoplasia (OSSN) in a patient with ulcerative colitis (UC).
A 32-year-old woman presented with sequential, progressive keratoconjunctival lesions in the left and right eyes, and both lesions were excised. Anterior segment optical coherence tomography demonstrated features similar to OSSN, whereas histological examination revealed severe reactive epithelial atypia mimicking severe dysplasia. Shortly after treatment of the second eye, the patient was diagnosed with UC. Residual disease improved dramatically in response to systemic corticosteroids.
Severe ocular surface epithelial atypia resembling OSSN may be seen in association with UC.
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Departments of *Ophthalmology;
‡Radiation Oncology, Duke University Medical Center, Durham, NC; and
§Department of Ophthalmology, Stanford University Medical Center, Palo Alto, CA.
Reprints: Prithvi Mruthyunjaya, MD, MHS, Department of Ophthalmology, Byers Eye Institute, 2462 Watson Court, Palo Alto, CA 94303 (e-mail: firstname.lastname@example.org).
P. Mruthyunjaya had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. The authors have no funding or conflicts of interest to disclose.
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Received September 10, 2016
Received in revised form November 29, 2016
Accepted December 01, 2016