Institutional members access full text with Ovid®

Share this article on:

Ocular Surface Epithelial Atypia Mimicking Squamous Neoplasia in Association With Ulcerative Colitis

Ong, Sally S. MD; Walter, Scott D. MD; Chen, Xi MD, PhD; Vora, Gargi K. MD; Daluvoy, Melissa MD; Proia, Alan D. MD, PhD; Mruthyunjaya, Prithvi MD, MHS

doi: 10.1097/ICO.0000000000001144
Case Report

Purpose: Inflammatory bowel disease may be associated with extraintestinal manifestations. We report a case of severe reactive epithelial atypia resembling ocular surface squamous neoplasia (OSSN) in a patient with ulcerative colitis (UC).

Methods: Case report.

Results: A 32-year-old woman presented with sequential, progressive keratoconjunctival lesions in the left and right eyes, and both lesions were excised. Anterior segment optical coherence tomography demonstrated features similar to OSSN, whereas histological examination revealed severe reactive epithelial atypia mimicking severe dysplasia. Shortly after treatment of the second eye, the patient was diagnosed with UC. Residual disease improved dramatically in response to systemic corticosteroids.

Conclusions: Severe ocular surface epithelial atypia resembling OSSN may be seen in association with UC.

Supplemental Digital Content is Available in the Text.

Departments of *Ophthalmology;

Pathology; and

Radiation Oncology, Duke University Medical Center, Durham, NC; and

§Department of Ophthalmology, Stanford University Medical Center, Palo Alto, CA.

Reprints: Prithvi Mruthyunjaya, MD, MHS, Department of Ophthalmology, Byers Eye Institute, 2462 Watson Court, Palo Alto, CA 94303 (e-mail:

P. Mruthyunjaya had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. The authors have no funding or conflicts of interest to disclose.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (

Received September 10, 2016

Received in revised form November 29, 2016

Accepted December 01, 2016

Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.