Clinical ScienceEnhancing Descemet Membrane Endothelial Keratoplasty in Postvitrectomy Eyes With the Use of Pars Plana InfusionSorkin, Nir MD; Einan-Lifshitz, Adi MD; Ashkenazy, Zach MD; Boutin, Tanguy MD; Showail, Mahmood MD; Borovik, Armand MD; Alobthani, Murad MD; Chan, Clara C. MD; Rootman, David S. MDAuthor Information Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada. Reprints: Nir Sorkin, MD, Department of Ophthalmology and Vision Sciences, Toronto Western Hospital, 399 Bathurst St, 6th Floor East Wing, Reception 1, Toronto, ON M5T 2S8, Canada (e-mail: [email protected]). The authors have no funding or conflicts of interest to disclose. Cornea: March 2017 - Volume 36 - Issue 3 - p 280-283 doi: 10.1097/ICO.0000000000001072 Buy Metrics Abstract Purpose: To present a modified surgical technique to perform Descemet membrane endothelial keratoplasty (DMEK) in previously vitrectomized eyes and to analyze its safety and efficacy. Methods: A retrospective analysis of previously vitrectomized eyes that underwent DMEK at Toronto Western Hospital was performed. The modified DMEK technique that was used included placement of a posterior pars plana infusion to reduce fluctuations in the anterior chamber depth and its excessive deepening. Results: Twelve eyes of 12 patients (5 females and 7 males) aged 65.3 ± 21.5 years were included. Mean best-corrected visual acuity improved significantly from 1.72 ± 0.62 logMAR (mean Snellen ∼20/1040) preoperatively to 1.01 ± 0.64 logMAR (mean Snellen ∼20/200) at 6 months postoperatively (P = 0.017). Mean donor endothelial cell density was 2658 ± 229 cells/mm2 preoperatively and 1732 ± 454 cells/mm2 at 6 months after the procedure (mean percentage cell loss of 31.8%) (P = 0.046). There were no significant intraoperative complications, and no graft failures. One eye had graft detachment, which resolved after 2 rebubbling procedures. One eye had retinal detachment, which was corrected surgically. Conclusions: The use of posterior pars plana infusion in previously vitrectomized eyes stabilizes the anterior segment during DMEK, allowing for performance of DMEK surgery, and can potentially reduce intraoperative and postoperative complications. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.