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Biomechanical Properties of the Cornea Measured With the Dynamic Scheimpflug Analyzer in Young Healthy Adults

Lee, Hun MD; Kang, David Sung Yong MD; Ha, Byoung Jin MD; Choi, Jin Young MD; Kim, Eung Kweon MD, PhD; Seo, Kyoung Yul MD, PhD; Kim, Ha Yan MS; Kim, Tae-im MD, PhD

doi: 10.1097/ICO.0000000000001001
Clinical Science

Purpose: To investigate the biomechanical properties of the cornea using the dynamic Scheimpflug analyzer in young healthy adults.

Methods: This prospective cross-sectional population study included 944 eyes of 472 participants aged 20 to 40 years. Participants underwent ophthalmic investigations, including evaluation of biomechanical properties of the cornea using the dynamic Scheimpflug analyzer, manifest refraction, and measurements of keratometric values by autokeratometry, intraocular pressure (IOP) by noncontact tonometer, central corneal thickness (CCT) by ultrasound, and white-to-white distance by Scheimpflug tomography. Statistical analyses included determination of the reference interval with a bootstrapping method, linear quantile mixed-effects model, and Spearman correlation analysis between the corneal biomechanical parameters and other variables (age, manifest refraction spherical equivalent, CCT, IOP, white-to-white, and keratometric values).

Results: The 90% CIs of all corneal biomechanical parameters demonstrated that the ranges of the 90% CIs for the reference data were almost identical with and without bootstrapping. Quantile regression to determine the fifth, 50th, and 95th percentiles of each corneal biomechanical parameter supported the findings from the nonparametric method with the 90% CIs. Correlation analysis showed significant correlations between the parameters and variables, but there was a relatively high Spearman correlation coefficient in the case of the correlations with the CCT and IOP.

Conclusions: Using data from a large population of young healthy adults, we developed a database of normal values for multiple corneal biomechanical parameters obtained from the dynamic Scheimpflug analyzer. We conclude that the biomechanical properties of the cornea are influenced by the CCT and IOP.

*Department of Ophthalmology, International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, South Korea;

The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, South Korea;

Eyereum Eye Clinic, Seoul, South Korea;

§Corneal Dystrophy Research Institute, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, South Korea; and

Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, South Korea.

Reprints: Tae-im Kim, MD, PhD, Department of Ophthalmology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemungu, Seoul 03722, South Korea (e-mail: tikim@yuhs.ac).

Supported in part by a grant from the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (HI14C2044), and by research funds of Catholic Kwandong University International St. Mary's Hospital.

The authors have no conflicts of interest to disclose.

Received April 18, 2016

Received in revised form June 29, 2016

Accepted July 05, 2016

Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.