Clinical ScienceNeutrophil-to-Lymphocyte Ratio Increases in Patients With Dry EyeSekeryapan, Berrak MD; Uzun, Feyzahan MD; Buyuktarakci, Seyma MD; Bulut, Asker MD; Oner, Veysi MDAuthor Information Department of Ophthalmology, Recep Tayyip Erdogan University Medical School, Rize, Turkey. Reprints: Berrak Sekeryapan, MD, Fener Mah. Yesilkent Apt. No: 11, Rize 53100, Turkey (e-mail: [email protected]). The authors have no funding or conflicts of interest to disclose. Received November 12, 2015 Received in revised form February 23, 2016 Accepted March 20, 2016 Cornea: July 2016 - Volume 35 - Issue 7 - p 983-986 doi: 10.1097/ICO.0000000000000872 Buy Metrics Abstract Purpose: To assess the neutrophil-to-lymphocyte ratio (NLR) as an indicator of inflammation in patients with non-Sjögren dry eye disease. Methods: Serum NLR and C-reactive protein values were determined in 33 patients with dry eye and in 32 controls. The NLR was calculated by dividing the neutrophil count by the lymphocyte count. Results: Characteristics of the dry eye and control groups were similar. The mean NLR value was 2.8 ± 1.4 (range: 1.1–6.1) in the dry eye group and 1.6 ± 0.7 (range: 0.8–2.8) in the control group (P = 0.002, t test). The mean C-reactive protein value was 0.6 ± 0.7 mg/dL (range: 0–2.3 mg/dL) in the dry eye group and 0.5 ± 0.6 mg/dL (range: 0–1.9 mg/dL) in the control group (P = 0.307, t test). Conclusions: The NLR values were found to be higher in patients with non-Sjögren dry eye than in controls. This result suggests that non-Sjögren dry eye disease may be associated with systemic inflammation or the NLR values may increase in local inflammatory ocular diseases. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.