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Corneal Power Measurement Obtained by Fourier-Domain Optical Coherence Tomography: Repeatability, Reproducibility, and Comparison With Scheimpflug and Automated Keratometry Measurements

Wang, Qinmei MD; Hua, Yanjun MD; Savini, Giacomo MD; Chen, Hao MD; Bao, Fangjun MD; Lin, Shishi MD; Lu, Weicong MD; Huang, Jinhai MD

doi: 10.1097/ICO.0000000000000564
Clinical Science

Purpose: To assess the repeatability and reproducibility of corneal power values obtained by a Fourier-domain optical coherence tomography (FD-OCT) system (RTVue) and to compare them with the values obtained by a Scheimpflug camera system (Pentacam HR) and by automated keratometry (IOL Master).

Methods: Thirty-two eyes from 32 healthy subjects were included in this prospective study. Two experienced observers measured each eye 3 consecutive times with the Pentacam, IOLMaster, and RTVue centered on either the pupil or corneal vertex. The conventional keratometry equivalent (CKE) and anterior (Ka), posterior (Kp), and net (Kn) corneal power values were determined.

Results: The corneal power values obtained by the RTVue showed high repeatability (all intraclass correlation coefficient >0.96) and reproducibility (coefficient of variation <1.0%). Pupil-centered FD-OCT performed slightly better than corneal vertex-centered FD-OCT. Mean corneal values had higher reproducibly than any of the individual values. CKE, Ka, Kp, and Kn obtained by FD-OCT were 0.62 to 0.68 diopters (D), 0.70 to 0.76 D, 0.11 to 0.13 D, and 0.93 to 0.94 D higher than those obtained by the Pentacam HR, respectively. CKE and Ka obtained with the RTVue were also 0.60 to 0.74 D higher than those obtained with the IOLMaster, respectively.

Conclusions: The corneal power measurements obtained by the RTVue FD-OCT system showed high repeatability and reproducibility. Measurements obtained by FD-OCT with pupil centration were more reproducible than those obtained by FD-OCT with corneal vertex centration. We recommend that pupil-centered FD-OCT be used in clinical applications. Neither RTVue versus Pentacam HR nor RTVue versus IOLMaster can be used interchangeably.

Supplemental Digital Content is Available in the Text.

*School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China;

Key Laboratory of Vision Science, Ministry of Health PR China, Wenzhou, Zhejiang, China; and

G. B. Bietti Foundation IRCCS, Rome, Italy.

Reprints: Jinhai Huang, MD, Eye Hospital of Wenzhou Medical University, 270 West Xueyuan Rd, Wenzhou, Zhejiang 325027, China (e-mail: vip999vip@163.com).

Supported in part by the Natural Science Foundation of China (81300807); Foundation of Wenzhou City Science & Technology Bureau (J20140014 and Y20120176); Zhejiang Provincial & Ministry of Health Research Fund For Medical Sciences (WKJ-ZJ-1530).

The authors have no funding or conflicts of interest to disclose.

Q. Wang and Y. Hua contributed equally as first authors.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.corneajrnl.com).

Received March 11, 2015

Received in revised form June 16, 2015

Accepted June 16, 2015

Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.