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Variability in Oculus Pentacam Tomographer Measurements in Patients With Keratoconus

Vianna, Lucas M. M. MD; Muñoz, Beatriz MSc; Hwang, Frank S. MD; Gupta, Arusha MD; Jun, Albert S. MD, PhD

doi: 10.1097/ICO.0000000000000344
Clinical Science
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Purpose: The aim of this study was to determine intertest variability of measurements taken by the Pentacam tomographer in eyes with keratoconus.

Methods: Three Pentacam measurements with 1-minute intervals were taken from 101 eyes (81 keratoconus and 20 controls) from 57 patients (47 keratoconus and 10 controls) by the same examiner and under the same conditions. Keratoconus eyes were divided into 3 subgroups based on topographic astigmatism (TA). Variability in astigmatism, mean keratometry, central corneal thickness, and fixation values were compared within the patient subgroups versus normal controls.

Results: Variability of all studied parameters (astigmatism, mean keratometry, central corneal thickness, and fixation values) increased with increasing TA in patients with keratoconus.

Conclusions: Pentacam measurements show increased variability in patients with keratoconus. The degree of variability correlates with TA.

*Cornea and Anterior Segment Service, Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD;

Department of Ophthalmology, Federal University of São Paulo/Paulista School of Medicine, São Paulo, Brazil;

Department of Ophthalmology, State University of Rio de Janeiro, Rio de Janeiro, Brazil;

§Dana Center for Preventive Ophthalmology, Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD;

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD;

Department of Ophthalmology, Wayne State University School of Medicine, Kresge Eye Institute, Detroit, MI; and

**Ophthalmology Unit, Medstar Washington Hospital Center, Washington, DC.

Reprints: Albert S. Jun, MD, PhD, 400 N. Broadway, Smith Building 5011, Baltimore, MD 21231 (e-mail: aljun@jhmi.edu).

Supported by a Research for Prevention of Blindness Unrestricted/Challenge Grant (to F.S.H.) and a Richard J. Kolker Research Grant Award (to A.G.).

The authors have no conflicts of interest to disclose.

Received October 01, 2014

Received in revised form November 09, 2014

Accepted November 11, 2014

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