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Treatment of Ocular Surface Squamous Neoplasia With Topical Aloe vera Drops

Damani, Mausam R. MD; Shah, Ankoor R. MD; Karp, Carol L. MD; Orlin, Stephen E. MD

doi: 10.1097/ICO.0000000000000296
Case Report

Purpose: To report a case of ocular surface squamous neoplasia (OSSN) that resolved with topical Aloe vera eye drop treatment.

Methods: A 64-year-old Hispanic woman with a lesion typical for OSSN in her left eye was followed up with multiple clinical examinations and ocular surface photographs to document changes over time with A. vera-based topical treatment.

Results: The patient refused biopsy of her lesion and traditional treatments and, instead, initiated using A. vera eye drops 3 times daily. At follow-up visits, the lesion was noted to regress until it finally resolved 3 months after commencing treatment. No additional topical medications were used, and she has remained tumor free for 6 years.

Conclusions: Ongoing research is warranted because A. vera may represent a new therapeutic class of medications for OSSN treatment.

*Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, PA; and

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, FL.

Reprints: Stephen E. Orlin, MD, University of Pennsylvania, Scheie Eye Institute, 51 North 39th Street, Philadelphia, PA 19104 (e-mail:

Supported by NIH Center Core Grant P30EY014801, RPB Unrestricted Award and Career Development Awards, Department of Defense (DOD, W81XWH-09-1-0675), The Ronald and Alicia Lepke Grant, The Lee and Claire Hager Grant, The Jimmy and Gaye Bryan Grant, and The Richard Azar Family Grant (institutional grants).

The authors have no conflicts of interest to disclose.

Received July 25, 2014

Received in revised form September 16, 2014

Accepted September 20, 2014

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