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Topographic and Biomechanical Evaluation of Cornea in Patients With Acromegaly

Altinkaynak, Hasan MD; Duru, Necati MD; Ersoy, Reyhan MD; Kalkan Akcay, Emine MD; Ugurlu, Nagihan MD; Cagil, Nurullah MD; Cakir, Bekir MD

doi: 10.1097/ICO.0000000000000297
Clinical Science

Purpose: The aim of this study was to compare topographic and biomechanical properties of corneas in patients with acromegaly with those of healthy individuals.

Methods: Thirty-five patients with acromegaly (study group) and 35 healthy individuals (control group) were enrolled in this prospective study. Topographic measurements, including central corneal thickness (CCT), mean keratometry (K) value, K1, K2, surface asymmetry index, corneal volume (CV), and anterior chamber depth in the right eye of each participant were obtained using a Scheimpflug camera with a Placido disc topographer (Sirius; Costruzione Strumenti Oftalmici). Corneal hysteresis (CH), corneal resistance factor (CRF), corneal-compensated intraocular pressure (IOP), and Goldmann-corelated intraocular pressure (IOPg) were measured using Reichert Ocular Response Analyzer (Reichert Ophthalmic Instruments).

Results: Mean CCT, CV, CH, CRF, and IOPg values were higher in acromegalic eyes (549.3 ± 30.2 μm, 59.1 ± 3.1 μm, 11.3 ± 1.2 mm Hg, 11.3 ± 1.2 mm Hg, and 17.5 ± 2.9 mm Hg, respectively) than in healthy eyes (531.4 ± 33.6 μm, 57.4 ± 2.7 μm, 10.4 ± 1.2 mm Hg, 10.2 ± 1.6 mm Hg, and 14.8 ± 3.1 mm Hg, respectively; CCT, P = 0.042; CV, P = 0.032; CH, P = 0.044; CRF, P = 0.035; IOPg, P < 0.001).

Conclusions: CCT, CV, CH, CRF, IOPg, and IOP with Goldmann applanation tonometry were significantly higher in acromegalic eyes. These corneal topographic and biomechanical properties, disease duration, and disease status should be considered when planning corneal refractive surgery and determining accurate intraocular pressure in patients with acromegaly.

Departments of *Ophthalmology, and

Endocrinology and Metabolism, Yildirim Beyazit University, Ankara Atatürk Education and Research Hospital, Ankara, Turkey.

Reprints: Hasan Altinkaynak, MD, Department of Ophthalmology, Yildirim Beyazit University, Ankara Ataturk Education and Research Hospital, Ankara, 06560 Turkey (e-mail:

The authors have no funding or conflicts of interest to disclose.

Received August 06, 2014

Received in revised form September 19, 2014

Accepted September 21, 2014

Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.