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Corneal Topographic Analysis of Patients With Mooren Ulcer Using 3-Dimensional Anterior Segment Optical Coherence Tomography

Yoshihara, Masahito MD; Maeda, Naoyuki MD, PhD; Soma, Takeshi MD, PhD; Fuchihata, Mutsumi MD, PhD; Hayashi, Asumi MD; Koh, Shizuka MD, PhD; Oie, Yoshinori MD, PhD; Nishida, Kohji MD, PhD

doi: 10.1097/ICO.0000000000000237
Clinical Science

Purpose: To investigate the corneal topography and visual function of patients with Mooren ulcer using 3-dimensional anterior segment optical coherence tomography (3-D AS-OCT).

Methods: Fourteen eyes of 9 patients with Mooren ulcer were studied. Pachymetric and axial power maps were obtained by 3-D AS-OCT. The axial power maps were classified into 3 patterns by visual inspection. The distribution of the corneal dioptric power was analyzed by Fourier harmonic expansion. The magnitudes of the spherical component, asymmetry, regular astigmatism, higher-order irregularity, and radial distance from the corneal vertex to the thinnest point of the lesion were determined.

Results: The axial power maps of 9 eyes were classified into arcuate patterns, 4 into crab-claw patterns, and 1 eye into an intermediate pattern. The radial distance from the corneal vertex to the thinnest point of the lesion was significantly shorter in the crab-claw pattern group than in the arcuate pattern group (P = 0.007). The magnitudes of asymmetry, regular astigmatism, and higher-order irregularity of the crab-claw pattern group were significantly greater than those of the arcuate pattern group (P = 0.017, P = 0.011, and P = 0.030, respectively).

Conclusions: Three-dimensional AS-OCT is able to evaluate the corneal topography of opacified peripheral lesions in eyes with Mooren ulcer, and the results showed that irregular astigmatism is higher when the lesion is closer to the center of the cornea.

*Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan; and

Department of Ophthalmology, Osaka National Hospital, Osaka, Japan.

Reprints: Naoyuki Maeda, MD, Department of Ophthalmology, Osaka University Graduate School of Medicine, Room E7, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan (e-mail:

Supported in part by a Grant-in-Aid, No. 24592669, for Scientific Research from the Japanese Ministry of the Education, Culture, Sports, Science and Technology.

N. Maeda received lecture fees from Tomey Corporation. The other authors have no conflicts of interest to disclose.

Received May 14, 2014

Received in revised form July 01, 2014

Accepted July 03, 2014

Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.