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Histological Analysis of a Cornea Following Experimental Femtosecond Laser Ablation

Sumioka, Takayoshi MD, PhD; Miyamoto, Takeshi MD, PhD; Takatsuki, Reiko MD, PhD; Okada, Yuka MD, PhD; Yamanaka, Osamu MD, PhD; Saika, Shizuya MD, PhD

doi: 10.1097/ICO.0000000000000251

Abstract: Corneal photorefractive surgery is currently performed by ablation of corneal stroma under the stromal flap. A stromal flap is created using a femtosecond (FS) laser or mechanical microkeratome, although the FS laser procedure is considered safer and more accurate. This review assesses and compares the use of FS laser versus mechanical microkeratome ablation for corneal stromal characteristics mainly examined by histology and cellular biological responses. Supporting data from our studies, using corneas of enucleated porcine eye globes, are included in this review. Histological analysis and experimental studies of cellular/tissue responses to FS laser irradiation should be further investigated, and the equipment used to perform these techniques should be improved.

*Department of Ophthalmology, Wakayama Medical University School of Medicine, Wakayama Japan; and

Takatsuki Eye Clinic, Osaka Japan.

Reprints: Takayoshi Sumioka, MD, PhD, Department of Ophthalmology, Wakayama Medical University School of Medicine, 811-1 Kimiidera, Wakayama 641-0012, Japan (e-mail:

Supported by grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan (C24791869 to T.S., C24592638 to Y.O., C25462759 to O.Y., C25462729 to S.S.).

The authors have no conflicts of interest to disclose.

Copyright © 2014 Wolters Kluwer Health, Inc. All rights reserved.