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Mitomycin-C for Mucous Membrane Overgrowth in OOKP Eyes

Avadhanam, Venkata S. MS, FRCS, FRCOphth; Herold, Jim FDRCS (Eng), FRCS (Ed), FRCS (Eng); Thorp, Simon MBChB, DA, MRCA, FCARCSI, FFPMCAI; Liu, Christopher S. C. FRCOphth

doi: 10.1097/ICO.0000000000000183
Case Report

Purpose: The aim of this study was to report the use of mitomycin-C (MMC) in the treatment of mucous membrane overgrowth in eyes with osteo-odonto-keratoprosthesis (OOKP).

Methods: Records of 4 cases with mucous membrane overgrowth after stage 2 OOKP surgery were reviewed.

Results: All the patients had undergone a mucous membrane trimming procedure followed by MMC application. None of the patients had any episode of recurrence of the mucous membrane overgrowth after a single application of MMC in the follow-up period that ranged from 1 to 11 years.

Conclusions: MMC can successfully arrest mucous membrane overgrowth in OOKP-implanted eyes including refractory cases.

*Sussex Eye Hospital, Brighton, United Kingdom;

Brighton and Sussex Medical School, Brighton, United Kingdom;

Royal Sussex County Hospital, Brighton, United Kingdom; and

§Tongdean Eye Clinic, Hove, United Kingdom.

Reprints: Christopher S. C. Liu, FRCOphth, Sussex Eye Hospital, Eastern Road, Brighton BN2 5BF, United Kingdom (e-mail:

The authors have no funding or conflicts of interest to disclose.

Received September 02, 2013

Accepted May 09, 2014

Copyright © 2014 Wolters Kluwer Health, Inc. All rights reserved.