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Multifocal Melanoma of the Conjunctiva in an African American Patient With Neurofibromatosis Type 1

Medina Mendez, Carlos A. MD; Singh, Arun D. MD

doi: 10.1097/ICO.0000000000000115
Case Report

Abstract: A 22-year-old African American female with neurofibromatosis type 1 and multifocal conjunctival melanoma with scleral invasion. The lesion was detected during pregnancy, and after early induction of childbirth, staging by sentinel lymph node biopsy and imaging studies were performed. Systemic evaluation was negative, and the patient was treated with excisional biopsy and cryotherapy. The recurrent multifocal melanoma with scleral extension was treated with brachytherapy by a 2-stage procedure. Follow-up at 2 years reveals the absence of recurrence and 20/25 visual acuity.

Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Cleveland, OH.

Reprints: Arun D. Singh, Department of Ophthalmic Oncology, Cleveland Clinic Cole Eye Institute, 9500 Euclid Ave, Desk i32, Cleveland, OH 44195 (e-mail

The authors have no funding or conflicts of interest to disclose.

Received February 03, 2014

Accepted February 13, 2014

Copyright © 2014 Wolters Kluwer Health, Inc. All rights reserved.