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Topography-Based Keratoconus Progression After Corneal Collagen Crosslinking

Kymionis, George D. MD, PhD; Karavitaki, Alexandra E. MD; Grentzelos, Michael A. MD; Liakopoulos, Dimitrios A. MD; Tsoulnaras, Konstantinos I. MD; Kontadakis, George A. MD, MSc

doi: 10.1097/ICO.0000000000000064
Case Report

Purpose: The aim of this study was to report 2 cases with topographic keratoconus progression despite stability for a long-term period after corneal collagen crosslinking (CXL).

Methods: This is a case report.

Results: Two patients with progressive keratoconus underwent CXL treatment. Four and 5 years postoperatively, a topographic examination revealed an increase in the keratometric values indicating keratoconus progression.

Conclusions: Post-CXL, topographic keratoconus progression may occur several years after, despite stability for a long-term period.

*Vardinoyiannion Eye Institute of Crete (VEIC), Faculty of Medicine, University of Crete, Heraklion, Greece; and

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, FL.

Reprints: George D. Kymionis, Vardinoyiannion Eye Institute of Crete (VEIC), Faculty of Medicine, University of Crete, 71003 Heraklion, Crete, Greece (e-mail:

The authors have no funding or conflicts of interest to disclose.

Received November 02, 2013

Accepted December 04, 2013

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