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Relationship Between IL1β-511C>T and ILRN VNTR Polymorphisms and Keratoconus

Palamar, Melis MD; Onay, Huseyin MD; Ozdemir, Taha Resid MD; Arslan, Esra MD; Egrilmez, Sait MD; Ozkinay, Ferda MD; Yagci, Ayse MD

doi: 10.1097/ICO.0000000000000027
Clinical Science

Purpose: The aim of this study was to evaluate the relationship between keratoconus (KC) and interleukin-1β (IL1 β) (–511C>T) and interleukin-1 receptor antagonist (IL1RN) variable number of tandem repeat (VNTR) polymorphisms that are potentially associated in their genetic susceptibility to KC.

Methods: A total of 121 patients with KC and 121 healthy individuals were enrolled. Blood samples with ethylenediamine tetraacetic acid were obtained, and IL1β (−511C>T) (rs16944) (polymerase chain reaction–restriction fragment length polymorphism method) and IL1RN VNTR polymorphisms (rs2234663) (polymerase chain reaction and agarose gel imaging) were investigated.

Results: Genotype and allele distribution for IL1β (−511C>T) and IL1RN VNTR polymorphisms among the KC and healthy groups showed no difference (for all; P > 0.05).

Conclusions: Because the genotype and allele frequency of both polymorphisms are identical, it is most likely that IL1β-511C>T and IL1RN VNTR polymorphisms do not play a role in the development of KC in the Turkish population.

Departments of *Ophthalmology and

Medical Genetics, Ege University Faculty of Medicine, Izmir, Turkey.

Reprints: Melis Palamar, Department of Ophthalmology, Faculty of Medicine, Ege University, 35100 Bornova, Izmir, Turkey (e-mail:

The authors have no funding or conflicts of interest to disclose.

Received July 19, 2013

Accepted October 07, 2013

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