To describe the technique and outcomes of limbal stem cell–sparing lamellar keratoplasty (LSCS-LKP) for the management of advanced keratoglobus (KGB).
In a sequential interventional case series from March 2010 to December 2012, 8 eyes of 6 patients with advanced KGB underwent an LSCS-LKP. Three patients had isolated KGB, 2 were affected with the Ehlers–Danlos syndrome, and the other subject had osteogenesis imperfecta. Epithelial healing, anatomical results (corneal thickness and keratometry), and visual outcomes were evaluated after this intervention.
Three of the 6 patients were male. Complete epithelial healing occurred in 7 eyes during 2 weeks. Refractory persistent epithelial defect and graft melting occurred in 1 eye. Corneal thickness increased and central keratometry decreased after the LSCS-LKP was performed in all the patients. The patients were followed up for at least 6 months. Visual acuity improved in all eyes except 1.
LSCS-LKP is an effective procedure for preserving ocular integrity and for improving visual acuity in patients with advanced KGB. Early surgical intervention can be considered before the occurrence of vision-threatening traumatic corneal rupture.
*Cornea and External Disease Service, Department of Ophthalmology, Shahid Beheshti University of Medical Sciences, Tehran, Iran; and
†Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Reprints: Farid Karimian, Department of Ophthalmology, Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran (e-mail: firstname.lastname@example.org).
The authors have no funding or conflicts of interest to disclose.
Received July 05, 2013
Accepted August 20, 2013